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ATP-citrate synthase Polyclonal Antibody
： Human;Mouse;Rat;Monkey
：WB;IF/ICC;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：ACLY
Product Information
Protein Name：ATP-citrate synthase
Human Gene Id：47
Human Swiss Prot No：P53396
Mouse Gene Id：104112
Mouse Swiss Prot No：Q91V92
Rat Gene Id：24159
Rat Swiss Prot No：P16638
Specificity：ATP-citrate synthase Polyclonal Antibody detects endogenous levels of ATP-citrate synthase protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme
Molecular Weight：120839DaObserved Band：120KD
Function：catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer.,
Subcellular Location：Cytoplasm, cytosol .
Expression：Brain,Epithelium,Hippocampus,Liver,Lymph,Platelet,
Immunogen：The antiserum was produced against synthesized peptide derived from human ATP-Citrate Lyase. AA range:420-469
Dilution：Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70415-Conjugate. Price: $485 / Size: 100μl.
：E20-70415-FITC$485 / 100μl：E20-70415-Biotin$485 / 100μl：E20-70415-HRP$485 / 100μl：E20-70415-AP$485 / 100μl：E20-70415-AF350$485 / 100μl：E20-70415-AF405M$485 / 100μl：E20-70415-AF488$485 / 100μl：E20-70415-AF514$485 / 100μl：E20-70415-AF532$485 / 100μl：E20-70415-AF555$485 / 100μl：E20-70415-AF568$485 / 100μl：E20-70415-AF405S$485 / 100μl：E20-70415-AF405L$485 / 100μl：E20-70415-AF546$485 / 100μl：E20-70415-AF594$485 / 100μl：E20-70415-AF610$485 / 100μl：E20-70415-AF635$485 / 100μl：E20-70415-AF647$485 / 100μl：E20-70415-AF680$485 / 100μl：E20-70415-AF700$485 / 100μl：E20-70415-AF750$485 / 100μl：E20-70415-AF790$485 / 100μl：E20-70415-APC$485 / 100μl：E20-70415-PE$485 / 100μl：E20-70415-Cy3$485 / 100μl：E20-70415-Cy5$485 / 100μl：E20-70415-Cy5.5$485 / 100μl：E20-70415-Cy7$485 / 100μl：E20-70415-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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