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ATF-6β Polyclonal Antibody

：E20-70389DatasheetCOAMSDS
： Human;Rat;Mouse;
： WB;IHC-p;IF(paraffin section);ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Gene Name：ATF6B

Product Information

Protein Name：Cyclic AMP-dependent transcription factor ATF-6 beta
Human Gene Id：1388
Human Swiss Prot No：Q99941
Mouse Swiss Prot No：O35451
Specificity：ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ATF6B; CREBL1; G13; Cyclic AMP-dependent transcription factor ATF-6 beta; cAMP-dependent transcription factor ATF-6 beta; Activating transcription factor 6 beta; ATF6-beta; Protein G13; cAMP response element-binding protein-related protein;
Molecular Weight：76709DaObserved Band：76KD
Function：domain:The basic domain functions as a nuclear localization signal.,domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,function:Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.,PTM:During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cy
Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .
Expression：Ubiquitous.
Immunogen：The antiserum was produced against synthesized peptide derived from human ATF6B. AA range:401-450
Dilution：Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: ：E20-70389-Conjugate. Price: $485 / Size: 100μl.

：E20-70389-FITC$485 / 100μl：E20-70389-Biotin$485 / 100μl：E20-70389-HRP$485 / 100μl：E20-70389-AP$485 / 100μl：E20-70389-AF350$485 / 100μl：E20-70389-AF405M$485 / 100μl：E20-70389-AF488$485 / 100μl：E20-70389-AF514$485 / 100μl：E20-70389-AF532$485 / 100μl：E20-70389-AF555$485 / 100μl：E20-70389-AF568$485 / 100μl：E20-70389-AF405S$485 / 100μl：E20-70389-AF405L$485 / 100μl：E20-70389-AF546$485 / 100μl：E20-70389-AF594$485 / 100μl：E20-70389-AF610$485 / 100μl：E20-70389-AF635$485 / 100μl：E20-70389-AF647$485 / 100μl：E20-70389-AF680$485 / 100μl：E20-70389-AF700$485 / 100μl：E20-70389-AF750$485 / 100μl：E20-70389-AF790$485 / 100μl：E20-70389-APC$485 / 100μl：E20-70389-PE$485 / 100μl：E20-70389-Cy3$485 / 100μl：E20-70389-Cy5$485 / 100μl：E20-70389-Cy5.5$485 / 100μl：E20-70389-Cy7$485 / 100μl：E20-70389-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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ATF-6β Polyclonal Antibody | EnoGene Biotech Co. Ltd