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ATF-1 Polyclonal Antibody
： Human;Rat;Mouse;
： WB;IHC-p;IF/ICC;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：ATF1
Product Information
Protein Name：Cyclic AMP-dependent transcription factor ATF-1
Human Gene Id：466
Human Swiss Prot No：P18846
Mouse Gene Id：11908
Mouse Swiss Prot No：P81269
Specificity：ATF-1 Polyclonal Antibody detects endogenous levels of ATF-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ATF1; Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36
Molecular Weight：29233DaObserved Band：36KD
Function：disease:A chromosomal aberration involving ATF1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein.,disease:A chromosomal aberration involving ATF1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.,function:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Binds DNA as a dimer.,
Subcellular Location：Nucleus .
Expression：Bone marrow,
Immunogen：The antiserum was produced against synthesized peptide derived from human ATF1. AA range:176-225
Dilution：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：activating transcription factor 1(ATF1) Homo sapiens This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chro
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70379-Conjugate. Price: $485 / Size: 100μl.
：E20-70379-FITC$485 / 100μl：E20-70379-Biotin$485 / 100μl：E20-70379-HRP$485 / 100μl：E20-70379-AP$485 / 100μl：E20-70379-AF350$485 / 100μl：E20-70379-AF405M$485 / 100μl：E20-70379-AF488$485 / 100μl：E20-70379-AF514$485 / 100μl：E20-70379-AF532$485 / 100μl：E20-70379-AF555$485 / 100μl：E20-70379-AF568$485 / 100μl：E20-70379-AF405S$485 / 100μl：E20-70379-AF405L$485 / 100μl：E20-70379-AF546$485 / 100μl：E20-70379-AF594$485 / 100μl：E20-70379-AF610$485 / 100μl：E20-70379-AF635$485 / 100μl：E20-70379-AF647$485 / 100μl：E20-70379-AF680$485 / 100μl：E20-70379-AF700$485 / 100μl：E20-70379-AF750$485 / 100μl：E20-70379-AF790$485 / 100μl：E20-70379-APC$485 / 100μl：E20-70379-PE$485 / 100μl：E20-70379-Cy3$485 / 100μl：E20-70379-Cy5$485 / 100μl：E20-70379-Cy5.5$485 / 100μl：E20-70379-Cy7$485 / 100μl：E20-70379-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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