World supplier of antibodies, antigens and kits since 2007
Other Products
Ataxin-2 Polyclonal Antibody
： Human;Rat;Mouse;
： WB;IHC-p;IF/ICC;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：ATXN2
Product Information
Protein Name：Ataxin-2
Human Gene Id：6311
Human Swiss Prot No：Q99700
Mouse Swiss Prot No：O70305
Specificity：Ataxin-2 Polyclonal Antibody detects endogenous levels of Ataxin-2 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ATXN2; ATX2; SCA2; TNRC13; Ataxin-2; Spinocerebellar ataxia type 2 protein; Trinucleotide repeat-containing gene 13 protein
Molecular Weight：140141DaObserved Band：140KD
Function：disease:Defects in ATXN2 are the cause of spinocerebellar ataxia type 2 (SCA2) [MIM:183090]; also known as olivopontocerebellar atrophy II (OPCA II or OPCA2). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is characterized by hyporeflexia, myoclonus and action tremor and dopamine-responsive parkinsonism. SCA2 is caused by expansion of a CAG repeat in the coding
Subcellular Location：Cytoplasm .
Expression：Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Immunogen：The antiserum was produced against synthesized peptide derived from human ATXN2. AA range:731-780
Dilution：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：ataxin 2(ATXN2) Homo sapiens This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The protein is primarily localized to the Golgi apparatus, with deletion of the Golgi and endoplasmic reticulum signals resulting in abnormal subcellular localization. In addition, the N-terminal region contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegener
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70374-Conjugate. Price: $485 / Size: 100μl.
：E20-70374-FITC$485 / 100μl：E20-70374-Biotin$485 / 100μl：E20-70374-HRP$485 / 100μl：E20-70374-AP$485 / 100μl：E20-70374-AF350$485 / 100μl：E20-70374-AF405M$485 / 100μl：E20-70374-AF488$485 / 100μl：E20-70374-AF514$485 / 100μl：E20-70374-AF532$485 / 100μl：E20-70374-AF555$485 / 100μl：E20-70374-AF568$485 / 100μl：E20-70374-AF405S$485 / 100μl：E20-70374-AF405L$485 / 100μl：E20-70374-AF546$485 / 100μl：E20-70374-AF594$485 / 100μl：E20-70374-AF610$485 / 100μl：E20-70374-AF635$485 / 100μl：E20-70374-AF647$485 / 100μl：E20-70374-AF680$485 / 100μl：E20-70374-AF700$485 / 100μl：E20-70374-AF750$485 / 100μl：E20-70374-AF790$485 / 100μl：E20-70374-APC$485 / 100μl：E20-70374-PE$485 / 100μl：E20-70374-Cy3$485 / 100μl：E20-70374-Cy5$485 / 100μl：E20-70374-Cy5.5$485 / 100μl：E20-70374-Cy7$485 / 100μl：E20-70374-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Primary Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- ELISA Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits
- Overexpression Cell Lines
- Cell Lysates
- Purification Resins
- 2019-nCoV & Monkeypox