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AR-β2 Polyclonal Antibody
： Human;Mouse;Rat;
： WB;IHC-p;IF/ICC;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：ADRB2
Product Information
Protein Name：Beta-2 adrenergic receptor
Human Gene Id：154
Human Swiss Prot No：P07550
Mouse Gene Id：11555
Mouse Swiss Prot No：P18762
Rat Swiss Prot No：P10608
Specificity：AR-β2 Polyclonal Antibody detects endogenous levels of AR-β2 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ADRB2; ADRB2R; B2AR; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor
Molecular Weight：46557DaObserved Band：46KD
Function：disease:Polymorphic forms of ADRB2 could impart some form of nocturnal asthma.,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.,PTM:Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.,PTM:Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the recep
Subcellular Location：Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). .
Expression：Blood,Brain,Fetal brain,Heart,Leukocyte,Prostate,Thyroid,
Immunogen：Synthesized peptide derived from AR-β2 . at AA range: 300-380
Dilution：Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70362-Conjugate. Price: $485 / Size: 100μl.
：E20-70362-FITC$485 / 100μl：E20-70362-Biotin$485 / 100μl：E20-70362-HRP$485 / 100μl：E20-70362-AP$485 / 100μl：E20-70362-AF350$485 / 100μl：E20-70362-AF405M$485 / 100μl：E20-70362-AF488$485 / 100μl：E20-70362-AF514$485 / 100μl：E20-70362-AF532$485 / 100μl：E20-70362-AF555$485 / 100μl：E20-70362-AF568$485 / 100μl：E20-70362-AF405S$485 / 100μl：E20-70362-AF405L$485 / 100μl：E20-70362-AF546$485 / 100μl：E20-70362-AF594$485 / 100μl：E20-70362-AF610$485 / 100μl：E20-70362-AF635$485 / 100μl：E20-70362-AF647$485 / 100μl：E20-70362-AF680$485 / 100μl：E20-70362-AF700$485 / 100μl：E20-70362-AF750$485 / 100μl：E20-70362-AF790$485 / 100μl：E20-70362-APC$485 / 100μl：E20-70362-PE$485 / 100μl：E20-70362-Cy3$485 / 100μl：E20-70362-Cy5$485 / 100μl：E20-70362-Cy5.5$485 / 100μl：E20-70362-Cy7$485 / 100μl：E20-70362-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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