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AR-β1 Polyclonal Antibody
： Human;Mouse;Rat;
： WB;IHC-p;IF/ICC;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：ADRB1
Product Information
Protein Name：Beta-1 adrenergic receptor
Human Gene Id：153
Human Swiss Prot No：P08588
Mouse Gene Id：11554
Mouse Swiss Prot No：P34971
Rat Gene Id：24925
Rat Swiss Prot No：P18090
Specificity：AR-β1 Polyclonal Antibody detects endogenous levels of AR-β1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ADRB1; ADRB1R; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor
Molecular Weight：51323DaObserved Band：51KD
Function：domain:The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.,PTM:Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.,subunit:Interacts with GOPC, MAGI3 and DLG4.,
Subcellular Location：Cell membrane ; Multi-pass membrane protein . Early endosome. Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. .
Expression：Placenta,
Immunogen：The antiserum was produced against synthesized peptide derived from human ADRB1. AA range:281-330
Dilution：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70359-Conjugate. Price: $485 / Size: 100μl.
：E20-70359-FITC$485 / 100μl：E20-70359-Biotin$485 / 100μl：E20-70359-HRP$485 / 100μl：E20-70359-AP$485 / 100μl：E20-70359-AF350$485 / 100μl：E20-70359-AF405M$485 / 100μl：E20-70359-AF488$485 / 100μl：E20-70359-AF514$485 / 100μl：E20-70359-AF532$485 / 100μl：E20-70359-AF555$485 / 100μl：E20-70359-AF568$485 / 100μl：E20-70359-AF405S$485 / 100μl：E20-70359-AF405L$485 / 100μl：E20-70359-AF546$485 / 100μl：E20-70359-AF594$485 / 100μl：E20-70359-AF610$485 / 100μl：E20-70359-AF635$485 / 100μl：E20-70359-AF647$485 / 100μl：E20-70359-AF680$485 / 100μl：E20-70359-AF700$485 / 100μl：E20-70359-AF750$485 / 100μl：E20-70359-AF790$485 / 100μl：E20-70359-APC$485 / 100μl：E20-70359-PE$485 / 100μl：E20-70359-Cy3$485 / 100μl：E20-70359-Cy5$485 / 100μl：E20-70359-Cy5.5$485 / 100μl：E20-70359-Cy7$485 / 100μl：E20-70359-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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