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Arrestin-β-1 Polyclonal Antibody
： Human;Mouse;Rat
： WB;IHC-p;IF/ICC;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：ARRB1
Product Information
Protein Name：Beta-arrestin-1
Human Gene Id：408
Human Swiss Prot No：P49407
Mouse Gene Id：109689
Mouse Swiss Prot No：Q8BWG8
Rat Gene Id：25387
Rat Swiss Prot No：P29066
Specificity：Arrestin-β-1 Polyclonal Antibody detects endogenous levels of Arrestin-β-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1
Molecular Weight：47066DaObserved Band：50KD
Function：function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
Subcellular Location：Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). .
Expression：Brain,Peripheral blood,Uterus,
Immunogen：The antiserum was produced against synthesized peptide derived from human ARRB1. AA range:369-418
Dilution：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70343-Conjugate. Price: $485 / Size: 100μl.
：E20-70343-FITC$485 / 100μl：E20-70343-Biotin$485 / 100μl：E20-70343-HRP$485 / 100μl：E20-70343-AP$485 / 100μl：E20-70343-AF350$485 / 100μl：E20-70343-AF405M$485 / 100μl：E20-70343-AF488$485 / 100μl：E20-70343-AF514$485 / 100μl：E20-70343-AF532$485 / 100μl：E20-70343-AF555$485 / 100μl：E20-70343-AF568$485 / 100μl：E20-70343-AF405S$485 / 100μl：E20-70343-AF405L$485 / 100μl：E20-70343-AF546$485 / 100μl：E20-70343-AF594$485 / 100μl：E20-70343-AF610$485 / 100μl：E20-70343-AF635$485 / 100μl：E20-70343-AF647$485 / 100μl：E20-70343-AF680$485 / 100μl：E20-70343-AF700$485 / 100μl：E20-70343-AF750$485 / 100μl：E20-70343-AF790$485 / 100μl：E20-70343-APC$485 / 100μl：E20-70343-PE$485 / 100μl：E20-70343-Cy3$485 / 100μl：E20-70343-Cy5$485 / 100μl：E20-70343-Cy5.5$485 / 100μl：E20-70343-Cy7$485 / 100μl：E20-70343-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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