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MMP2Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E90317

  • Amount:

    100ul

  • Background:

    The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5).

  • Species:

    Rabbit

  • Isotype:

    IgG

  • Storage/Stability:

    Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

  • Altername:

    MMP2;CLG4;CLG4A;MMP-II;MONA;TBE-1 ;

  • Immunogen:

    Fusionproteinof human MMP2

  • Purification:

    Affinity purification

  • Reactivity:

    H M R

  • Applications:

    WB IHC

  • Molecular Weight:

    72kDa

  • Swiss-Prot No.:

    P08253

  • Gene ID:

    4313

  • References:

    1. McCawley, L.J. and Matrisian, L.M. (2001) Curr. Opin. Cell Biol. 13, 534-540. 2. Coussens, L.M. et al. (2002) Science 295, 2387-2391. 3. Sternlicht, M.D. et al. (1999) Cell 98, 137-146. 4. Vu, T.H. et al. (1998) Cell 93, 411-422. 5. Nagase, H. et al. (1990) Biochemistry 29, 5783-5789.
    WB 1:200 - 1:500
    IHC 1:50- 1:100

  • Western blot analysis of MCF7 cell lysate using MMP2 antibody.

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