You are here: EnoGene Home > Products > BMP7 Antibody (C-term)

BMP7 Antibody (C-term)
Datasheet   

  • Catalog Number:

    E45R31167G-4

  • Amount:

    50 µl

  • Cite ID#:

    EN5477262

  • Price:

    295$

  • Type:

    Rabbit Polyclonal Antibody

  • Host:

    Rabbit

  • Reactivity:

    H, M

  • Immunogen:

    This BMP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human BMP7.

  • Purification:

    Affinity chromatography purified.

  • Gene Name:

    BMP7

  • Gene ID:

    655

  • Swiss-Prot No.:

    P18075

  • Function:

    Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061).

  • Summary:

    Tissue Location:
    Expressed in the kidney and bladder. Lower levels seen in the brain

  • Form:

    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

  • Storage/Stability:

    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

  • Applications:

    WB, IHC-P

  • Dilution:

    WB--1:1000
    IHC-P--1:100~500

  • Altername:

    Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, Eptotermin alfa, BMP7, OP1

Related Products

Catalog Number

  • Amount:50 µl
  • Price:295.00$

AbPromise

Contact us