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CD8B1 Antibody (C-term)
Datasheet   

  • Catalog Number:

    E45R30872G-4

  • Amount:

    50 µl

  • Cite ID#:

    EN5476967

  • Price:

    295$

  • Type:

    Rabbit Polyclonal Antibody

  • Host:

    Rabbit

  • Reactivity:

    H

  • Immunogen:

    This CD8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-167 amino acids from the C-terminal region of human CD8B1.

  • Purification:

    Affinity chromatography purified.

  • Gene Name:

    CD8B

  • Gene ID:

    926

  • Swiss-Prot No.:

    P10966

  • Function:

    Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T- cells.

  • Summary:

    Tissue Location:
    Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T- cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells

  • Form:

    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

  • Storage/Stability:

    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

  • Applications:

    WB

  • Dilution:

    WB--1:1000

  • Altername:

    T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1

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  • Amount:50 µl
  • Price:295.00$

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