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Dmap1 (NM_023178) Mouse Recombinant Protein
Datasheet   

  • Catalog Number:

    E45M46185M5

  • Amount:

    20 ug

  • Cite ID#:

    EN5431993

  • Price:

    1925$

  • Type:

    Recombinant Proteins

  • Product Description:

    Purified recombinant protein of Mouse DNA methyltransferase 1-associated protein 1 (Dmap1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

  • Protein length:

    A DNA sequence from Mouse cDNA ORF Clone, [GM36900V], encoding Mouse full-length Dmap1.

  • Expression Host:

    HEK293T

  • Species:

    Mouse

  • Molecular Weight:

    53.1 kDa

  • Gene symbol:

    Dmap1

  • Gene ID:

    66233

  • mRNA Refseq:

    NM_023178

  • Protein Refseq:

    NP_075667

  • Swiss-Prot No.:

    Q9JI44

  • Chromosome location:

    4 D2.1

  • Summary:

    Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity).[UniProtKB/Swiss-Prot Function]

  • Form:

    Liquid

  • Concentration:

    >50 ug/mL as determined by microplate BCA method

  • Purity:

    > 80% as determined by SDS-PAGE and Coomassie blue staining

  • Storage/Stability:

    Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

  • Storage Buffer:

    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

  • Synonyms:

    1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1; mKIAA1425

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  • Amount:20 ug
  • Price:1925.00$

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