You are here: EnoGene Home > Products > Dis3 (BC027357) Mouse Recombinant Protein

Dis3 (BC027357) Mouse Recombinant Protein
Datasheet   

  • Catalog Number:

    E45M45669M5

  • Amount:

    20 ug

  • Cite ID#:

    EN5431490

  • Price:

    1925$

  • Type:

    Recombinant Proteins

  • Product Description:

    Purified recombinant protein of Mouse DIS3 mitotic control homolog (S. cerevisiae) (cDNA clone MGC:37123 IMAGE:4952415), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

  • Protein length:

    A DNA sequence from Mouse cDNA ORF Clone, [GM38255V], encoding Mouse full-length Dis3.

  • Expression Host:

    HEK293T

  • Species:

    Mouse

  • Molecular Weight:

    64.6 kDa

  • Gene symbol:

    Dis3

  • Gene ID:

    72662

  • mRNA Refseq:

    BC027357

  • Swiss-Prot No.:

    Q9CSH3

  • Chromosome location:

    14 E2.2

  • Summary:

    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.[UniProtKB/Swiss-Prot Function]

  • Form:

    Liquid

  • Concentration:

    >50 ug/mL as determined by microplate BCA method

  • Purity:

    > 80% as determined by SDS-PAGE and Coomassie blue staining

  • Storage/Stability:

    Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

  • Storage Buffer:

    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

  • Synonyms:

    2810028N01Rik

Related Products

Catalog Number

  • Amount:20 ug
  • Price:1925.00$

AbPromise

Contact us