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Cathepsin L (CTSL) Mouse Monoclonal Antibody [Clone 5A5]
Datasheet   

  • Catalog Number:

    E45M20923V-2

  • Amount:

    50 ul

  • Cite ID#:

    EN5457078

  • Price:

    195$

  • Type:

    Mouse Monoclonal Antibody

  • Research Field:

    Antigen processing and presentation, Lysosome

  • Product Description:

    CTSL mouse monoclonal antibody,Clone 5A5

  • Host:

    Mouse

  • Reactivity:

    Human

  • Immunogen:

    Human recombinant protein fragment corresponding to amino acids 114-333 of human CTSL (NP_001903) produced in E.coli.

  • Target:

    CTSL

  • Clone Number:

    Clone 5A5

  • Isotype:

    IgG1

  • Purification:

    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

  • Gene Name:

    cathepsin L

  • Gene symbol:

    CTSL

  • Gene ID:

    1514

  • Swiss-Prot No.:

    P07711

  • Pathway:

    Antigen processing and presentation, Lysosome

  • Function:

    Druggable Genome, Protease

  • Summary:

    The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

  • Form:

    PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage/Stability:

    Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

  • Applications:

    WB 1:500

  • Synonyms:

    CATL; CTSL1; MEP

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