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MASP2 Mouse Monoclonal Antibody [Clone 7C4]
Datasheet   

  • Catalog Number:

    E45M20773V-2

  • Amount:

    50 ul

  • Cite ID#:

    EN5456928

  • Price:

    195$

  • Type:

    Mouse Monoclonal Antibody

  • Research Field:

    Complement and coagulation cascades

  • Product Description:

    MASP2 mouse monoclonal antibody,Clone 7C4

  • Host:

    Mouse

  • Reactivity:

    Human

  • Immunogen:

    Human recombinant protein fragment corresponding to amino acids 445-686 of human MASP2 (NP_006601) produced in E.coli.

  • Target:

    MASP2

  • Clone Number:

    Clone 7C4

  • Isotype:

    IgG2b

  • Purification:

    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

  • Gene Name:

    mannan binding lectin serine peptidase 2

  • Gene symbol:

    MASP2

  • Gene ID:

    10747

  • Swiss-Prot No.:

    O00187

  • Pathway:

    Complement and coagulation cascades

  • Function:

    Druggable Genome, Protease, Secreted Protein

  • Summary:

    This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

  • Form:

    PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage/Stability:

    Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

  • Applications:

    WB 1:500

  • Synonyms:

    MAP-2; MAP19; MASP-2; MASP1P1; sMAP

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