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Constitutive androstane receptor (NR1I3) Mouse Monoclonal Antibody [Clone 1C6]
Datasheet   

  • Catalog Number:

    E45M16874V-2

  • Amount:

    50 ul

  • Cite ID#:

    EN5453029

  • Price:

    195$

  • Type:

    Mouse Monoclonal Antibody

  • Product Description:

    NR1I3 mouse monoclonal antibody, Clone 1C6

  • Host:

    Mouse

  • Reactivity:

    Human

  • Immunogen:

    Human recombinant protein fragment corresponding to amino acids 1-236 of human NR1I3 (NP_001070950) produced in E.coli.

  • Target:

    NR1I3

  • Clone Number:

    Clone 1C6

  • Isotype:

    IgG1

  • Purification:

    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

  • Gene Name:

    nuclear receptor subfamily 1 group I member 3

  • Gene symbol:

    NR1I3

  • Gene ID:

    9970

  • Swiss-Prot No.:

    Q14994

  • Function:

    Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

  • Summary:

    This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • Form:

    PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage/Stability:

    Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

  • Applications:

    WB 1:2000, IHC 1:150

  • Synonyms:

    CAR; CAR1; MB67

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