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Isocitrate dehydrogenase (IDH1) Mouse Monoclonal Antibody [Clone:3G9]
Datasheet   

  • Catalog Number:

    E45M14565

  • Amount:

    100 ug

  • Cite ID#:

    EN5467131

  • Price:

    595$

  • Type:

    Mouse Monoclonal Antibody

  • Research Field:

    Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways

  • Product Description:

    Carrier-free (BSA/glycerol-free) IDH1 mouse monoclonal antibody, clone LBI3G9

  • Host:

    Mouse

  • Reactivity:

    Human, Mouse, Rat, Dog

  • Immunogen:

    Synthetic peptide around the R132H mutation region of the human IDH conjugated to KLH

  • Target:

    IDH1

  • Conjugation:

    Unconjugated

  • Clone Number:

    Clone:3G9

  • Isotype:

    IgG1

  • Purification:

    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

  • Gene Name:

    Homo sapiens isocitrate dehydrogenase (NADP(+)) 1 (IDH1), transcript variant 1, mRNA.

  • Gene symbol:

    IDH1

  • Gene ID:

    3417

  • Swiss-Prot No.:

    O75874

  • Pathway:

    Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways

  • Summary:

    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008]

  • Form:

    Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

  • Storage/Stability:

    Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

  • Storage Buffer:

    Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

  • Applications:

    WB 1:2000, IHC 1:150

  • Synonyms:

    HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD

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  • Amount:100 ug
  • Price:595.00$

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