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Aminoacylase 1 (ACY1) Mouse Monoclonal Antibody [Clone 1E5]
Datasheet   

  • Catalog Number:

    E45M11509V-2

  • Amount:

    50 ul

  • Cite ID#:

    EN5447664

  • Price:

    195$

  • Type:

    Mouse Monoclonal Antibody

  • Research Field:

    Arginine and proline metabolism, Metabolic pathways

  • Product Description:

    ACY1 (Aminoacylase 1) mouse monoclonal antibody, Clone 1E5

  • Host:

    Mouse

  • Reactivity:

    Human, Mouse, Rat

  • Immunogen:

    Full length human recombinant protein of human ACY1(NP_000657) produced in HEK293T cell.

  • Target:

    ACY1

  • Clone Number:

    Clone 1E5

  • Isotype:

    IgG1

  • Purification:

    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

  • Gene Name:

    aminoacylase 1

  • Gene symbol:

    ACY1

  • Gene ID:

    95

  • Swiss-Prot No.:

    Q03154

  • Pathway:

    Arginine and proline metabolism, Metabolic pathways

  • Function:

    Protease

  • Summary:

    This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq]

  • Form:

    PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage/Stability:

    Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

  • Applications:

    WB 1:2000, FLOW 1:100

  • Synonyms:

    ACY-1; ACY1D; HEL-S-5

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