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emopamil binding protein (EBP) (NM_006579) Human Recombinant Protein
Datasheet   

  • Catalog Number:

    E45H41274M5

  • Amount:

    20 ug

  • Cite ID#:

    EN5443705

  • Price:

    785$

  • Type:

    Recombinant Proteins

  • Research Field:

    Metabolic pathways, Steroid biosynthesis

  • Product Description:

    Recombinant protein of human emopamil binding protein (sterol isomerase) (EBP)

  • Protein length:

    Recombinant protein was produced with GoldORF clone, [GH31687V]. Click on the GoldORF clone link to view cDNA and protein sequences.

  • Expression Host:

    HEK293T

  • Species:

    Human

  • Molecular Weight:

    26.2 kDa

  • Gene symbol:

    EBP

  • Gene ID:

    10682

  • mRNA Refseq:

    NM_006579

  • Protein Refseq:

    NP_006570

  • Swiss-Prot No.:

    Q15125, A0A024QYX0

  • Chromosome location:

    Xp11.23

  • Pathway:

    Metabolic pathways, Steroid biosynthesis

  • Function:

    Druggable Genome, Transmembrane

  • Summary:

    The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]

  • Form:

    Liquid

  • Concentration:

    >50 ug/mL as determined by microplate BCA method

  • Purity:

    > 80% as determined by SDS-PAGE and Coomassie blue staining

  • Storage/Stability:

    Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

  • Storage Buffer:

    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

  • Synonyms:

    CDPX2; CHO2; CPX; CPXD; MEND

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  • Amount:20 ug
  • Price:785.00$

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