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NCX1 Rabbit Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E28PT5103

  • Amount:

    100ul

  • Price:

    255$

  • Altername:

    SLC8A1; CNC; NCX1; Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1

  • Gene Name:

    SLC8A1

  • Protein Name:

    Sodium/calcium exchanger 1

  • Applications:

    WB,ELISA

  • Reactivity:

    Human,Mouse,Rat

  • Concentration:

    1 mg/ml

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

  • Human Gene Id:

    6546

  • Swiss-Prot No.:

    P32418

  • Mouse Gene Id:

    20541

  • Mouse Swiss Prot No:

    P70414

  • Rat Gene Id:

    29715

  • Rat Swiss Prot No:

    Q01728

  • Immunogen:

    Synthesized peptide derived from NCX1 . at AA range: 270-350

  • Specificity:

    NCX1 Polyclonal Antibody detects endogenous levels of NCX1 protein.

  • Recommended Dilutions:

    WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

  • Predicted Molecular Weight:

    108kD

  • Form of Antibody:

    Liquid

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Source:

    Polyclonal, Rabbit,IgG

  • Background:

    In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004],

  • Tissue Expression:

    Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165).

  • Cellular localization:

    Cell membrane ; Multi-pass membrane protein .

  • Signaling Pathway:

    Calcium;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;

  • Function:

    alternative products:Additional isoforms seem to exist,enzyme regulation:By ATP.,function:Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.,similarity:Contains 2 Calx-beta domains.,tissue specificity:Cardiac sarcolemma.,

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Western Blot analysis of extracts from 293 cells, using NCX1 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

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  • Amount:100ul
  • Price:255.00$

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