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PDE2A Rabbit Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E28PN0582

  • Amount:

    100ul

  • Price:

    255$

  • Gene Name:

    PDE2A

  • Protein Name:

    cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)

  • Applications:

    WB,ELISA

  • Reactivity:

    Human,Mouse,Rat

  • Concentration:

    1 mg/ml

  • Formulation:

    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

  • Human Gene Id:

    5138

  • Swiss-Prot No.:

    O00408

  • Mouse Swiss Prot No:

    Q922S4

  • Rat Swiss Prot No:

    Q01062

  • Immunogen:

    Synthesized peptide derived from part region of human protein

  • Specificity:

    PDE2A Polyclonal Antibody detects endogenous levels of protein.

  • Recommended Dilutions:

    WB 1:500-2000 ELISA 1:5000-20000

  • Predicted Molecular Weight:

    103kD

  • Form of Antibody:

    Liquid

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Source:

    Polyclonal, Rabbit,IgG

  • Background:

    alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subunit:Homodimer.,tissue specificity:Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.,

  • Tissue Expression:

    Widely expressed (PubMed:9210593, PubMed:29392776). Expressed in brain, with high expression observed in the corpus striatum (PubMed:29392776). Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas (PubMed:9210593, PubMed:29392776).

  • Cellular localization:

    [Isoform PDE2A3]: Cell membrane ; Lipid-anchor .; [Isoform PDE2A2]: Mitochondrion matrix . Mitochondrion inner membrane . Mitochondrion outer membrane .; [Isoform PDE2A1]: Cytoplasm .; [Isoform 5]: Mitochondrion .

  • Signaling Pathway:

    Purine metabolism;

  • Function:

    alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subunit:Homodimer.,tissue specificity:Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.,

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Western Blot analysis of Hela lysis, using primary antibody at 1:1000 dilution. Secondary antibody was diluted at 1:10000

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  • Amount:100ul
  • Price:255.00$

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