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B4GT7 Rabbit Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E28PN0504

  • Amount:

    100ul

  • Price:

    255$

  • Gene Name:

    B4GALT7 XGALT1 UNQ748/PRO1478

  • Protein Name:

    Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) [Includes: Xylosylprotein 4-beta-galactosyltransferase (EC 2.4.1.133) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein beta-1,4-galactosyltransferase)]

  • Applications:

    WB,ELISA

  • Reactivity:

    Human,Mouse

  • Concentration:

    1 mg/ml

  • Formulation:

    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

  • Human Gene Id:

    11285

  • Swiss-Prot No.:

    Q9UBV7

  • Mouse Swiss Prot No:

    Q8R087

  • Immunogen:

    Synthesized peptide derived from part region of human protein

  • Specificity:

    B4GT7 Polyclonal Antibody detects endogenous levels of protein.

  • Recommended Dilutions:

    WB 1:500-2000 ELISA 1:5000-20000

  • Predicted Molecular Weight:

    35kD

  • Form of Antibody:

    Liquid

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Source:

    Polyclonal, Rabbit,IgG

  • Background:

    This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. M

  • Tissue Expression:

    High expression in heart, pancreas and liver, medium in placenta and kidney, low in brain, skeletal muscle and lung.

  • Cellular localization:

    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cis cisternae of Golgi stack.

  • Signaling Pathway:

    Chondroitin sulfate biosynthesis;Heparan sulfate biosynthesis;

  • Function:

    catalytic activity:UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein.,cofactor:Manganese.,disease:Defects in B4GALT7 are the cause of progeroid Ehlers-Danlos syndrome (EDS) [MIM:130070]. EDSP is a variant form of Ehlers-Danlos syndrome characterized by progeroid facies, mild mental retardation, short stature, skin hyperextensibility, moderate skin fragility, joint hypermobility principally in digits.,function:Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.,online information:Beta-1,4-galactosyltransferase 7,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 7 family.,subcellular location:Cis cisternae of Golgi stack.,tissue specificity:High expression in heart, pancreas and liver, medium in placenta and kidney, low in brain, skeletal muscle and lung.,

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night

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  • Amount:100ul
  • Price:255.00$

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