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HDAC9 Rabbit Polyclonal Antibody (N-term)
Datasheet   

  • Catalog Number:

    E28PB0882

  • Amount:

    100ul

  • Price:

    255$

  • Altername:

    Histone deacetylase 9, HD9, Histone deacetylase 7B, HD7, HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR

  • Applications:

    WB, IP, IF, IHC-P

  • Reactivity:

    Human, Mouse

  • Human Gene Id:

    NP_001191073.1;NP_001191074.1;NP_001191075.1;NP_001191076.1;NP_001191077.1;NP_055522.1;NP_478056.1;NP_848510.1;NP_848512.1

  • Swiss-Prot No.:

    Q9UKV0

  • Specificity:

    This HDAC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HDAC9.

  • Recommended Dilutions:

    WB~~1:1000;IP~~1:100;IF~~1:1,000;IHC-P~~1:100~500

  • Predicted Molecular Weight:

    111kDa

  • Form of Antibody:

    Liquid

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Isotype:

    Rabbit Ig

  • Background:

    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

  • Tissue Expression:

    Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).

  • Cellular localization:

    Nucleus.

  • Purification:

    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

  • Both anti-HDAC9 N-term and C-term Pab were tested by WB and IP-WB using HeLa and HeLa-HDAC9 transfected cells. Top figure shows both Pab specifically detect HDAC9 in HeLa-HDAC9 transfected cell but not HeLa alone.

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  • Amount:100ul
  • Price:255.00$

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