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EBI3 (1O7) Rabbit Monoclonal Antibody
Datasheet   

  • Catalog Number:

    E28M6408

  • Amount:

    100ul

  • Cite ID#:

    EN5543854

  • Price:

    295$

  • Applications:

    WB

  • Reactivity:

    Human,Mouse,Rat

  • Type:

    Rabbit Monoclonal Antibody

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Altername:

    EBI3; IL-27B; IL27 subunit beta; IL27B; interleukin 27 subunit beta;

  • Gene Name:

    EBI3

  • Protein Name:

    IL27B

  • Formulation:

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

  • Human Gene Id:

    10148

  • Swiss-Prot No.:

    Q14213

  • Recommended Dilutions:

    WB 1:500~1:2000

  • Predicted Molecular Weight:

    25kDa

  • Form of Antibody:

    Liquid

  • Isotype:

    Rabbit IgG

  • Cellular localization:

    Secreted.

  • Description:

    Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells.

  • Function:

    Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN- gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

  • Western blot analysis of EBI3 expression in K562 cell lysate.

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