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HP1 gamma (8Y11) Rabbit Monoclonal Antibody
Datasheet   

  • Catalog Number:

    E28M5432

  • Amount:

    100ul

  • Cite ID#:

    EN5542884

  • Price:

    295$

  • Applications:

    WB,IHC,FC,IP

  • Reactivity:

    Human,Mouse,Rat

  • Type:

    Rabbit Monoclonal Antibody

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Altername:

    Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein; CBX3; HP1 gamma;

  • Gene Name:

    CBX3

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

  • Human Gene Id:

    11335

  • Swiss-Prot No.:

    Q13185

  • Immunogen:

    A synthetic peptide of human HP1 gamma

  • Recommended Dilutions:

    WB: 1:1000 IHC: 1:20 FC: 1:20-1:100 IP: 1:20

  • Molecular Weight:

    21kDa

  • Predicted Molecular Weight:

    21kDa

  • Form of Antibody:

    Liquid

  • Isotype:

    Rabbit IgG

  • Cellular localization:

    Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin May be associated with microtubules and mitotic poles during mitosis (Potential).

  • Description:

    Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

  • Function:

    Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

  • Western blot analysis of HP1 gamma expression in (1) HeLa cell lysate; (2) NIH/3T3 cell lysate.

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