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Phospho-GluR1 (S845) (7O5) Rabbit Monoclonal Antibody
Datasheet   

  • Catalog Number:

    E28M4771

  • Amount:

    100ul

  • Cite ID#:

    EN5542236

  • Price:

    295$

  • Applications:

    WB

  • Reactivity:

    Human,Mouse,Rat

  • Type:

    Rabbit Monoclonal Antibody

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Altername:

    Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; GluRA; GluRK1; Glutamate receptor ionotropic, AMPA 1; GluA1; GRIA1; GLUH1; GLUR1;

  • Gene Name:

    GRIA1

  • Protein Name:

    GLUH1, GLUR1

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

  • Human Gene Id:

    2890

  • Swiss-Prot No.:

    P42261

  • Immunogen:

    A synthetic phosphopeptide corresponding to residues surrounding Ser845 of human AMPA Receptor 1 (GluA1)

  • Recommended Dilutions:

    WB: 1:1000

  • Molecular Weight:

    102kDa

  • Predicted Molecular Weight:

    102kDa

  • Form of Antibody:

    Liquid

  • Isotype:

    Rabbit IgG

  • Tissue Expression:

    Widely expressed in brain.

  • Cellular localization:

    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane {ECO:0000250|UniProtKB:P23818}; Multi- pass membrane protein {ECO:0000250|UniProtKB:P23818}. Cell projection, dendrite {ECO:0000250|UniProtKB:P23818}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P23818}. Early endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Recycling endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000250|UniProtKB:P23818}

  • Description:

    AMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainate-, and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4), which assemble as homo- or hetero-tetramers to mediate the majority of fast excitatory transmissions in the central nervous system. AMPARs are implicated in synapse formation, stabilization, and plasticity.

  • Function:

    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

  • Western blot analysis of Phospho-GluR1 (S845) expression in (1) Human brain lysate treated with Lambda phosphatase lysate; (2) Human brain lysate.

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  • Amount:100ul
  • Price:295.00$

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