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p130 (9K6) Rabbit Monoclonal Antibody
Datasheet   

  • Catalog Number:

    E28M3445

  • Amount:

    100µl

  • Cite ID#:

    EN5550016

  • Price:

    295$

  • Reactivity:

    Human,Mouse,Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

  • Immunogen:

    A synthetic peptide of human p130

  • Applications:

    WB: 1:1000 IHC: 1:100 FC: 1:50

  • Molecular Weight:

    130kDa

  • Storage/Stability:

    Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

  • Species:

    Rabbit

  • Isotype:

    IgG

  • Background:

    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

  • Purification:

    Antigen specific affinity purification

  • Swiss-Prot No.:

    Q08999

  • Gene ID:

    5934

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