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Smad3 Mouse mAb (4H4)
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  • Catalog Number:

    E2251223

  • Amount:

    100ul

  • Price:

    225$

  • Swiss-Prot No.:

    P84022

  • Altername:

    SMAD3

  • Storage/Stability:

    Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

  • Immunogen:

    Purified recombinant protein expressed in E.coli.

  • Purification:

    Affinity purified

  • Reactivity:

    Human,Rat,Mouse

  • Other Names:

    hMAD3, HSPC193, LDS1C, MADH3, JV15 2

  • Background:

    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

  • Gene ID:

    4088

  • Cellular localization:

    Cytoplasm, Nucleus

  • Source:

    Mouse

  • Antibody type:

    Monclonal antibody

  • Isotype:

    IgG1

  • Molecular Weight:

    50kDa

  • Preservative:

    PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

  • Recommended Dilutions:

    WB 1:1,000-2,000 IHC 1:100-200 (Optimal dilutions should be determined by the end user)

  • Clone Number:

    4H4-10A10-7B4

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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  • Amount:100ul
  • Price:225.00$

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