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CRTC1 Mouse mAb
Datasheet   

  • Catalog Number:

    E2200541

  • Amount:

    100ul

  • Source:

    Mouse

  • Form of Antibody:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Specificity/Sensitivity:

    This antibody detects endogenous levels of TORC1(N-terminus) and does not cross-react with related proteins.

  • Entrez summary:

    null

  • UniPort summary Function:

    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses (By similarity)

  • Immunogen:

    Purified recombinant human MECT1 / Torc1 protein fragments expressed in E.coli.

  • Antibody type:

    Monoclonal Antibody

  • Isotype:

    IgG2b

  • Purification:

    Affinity Purified

  • Cellular localization:

    Cytoplasm. Nucleus

  • Reactivity:

    Human

  • Applications:

    WB,ICC/IF,IP,FC

  • Molecular Weight:

    Calculated MW: 67 kDa; Observed MW: 78 kDa

  • UniProt Number:

    Q6UUV9

  • Gene ID:

    23373

  • Gene symbol:

    MECT1; TORC1; WAMTP1

  • Altername:

    MECT1; TORC1; WAMTP1; FLJ14027; KIAA0616; CRTC1

  • Western blot analysis of MECT1 / Torc1 in Hela and Jurkat lysates using MECT1 / Torc1
    antibody.

  • Immunocytochemistry analysis of CRTC1 in Hela using MECT1 / Torc1 antibody.

  • Price:

    255$

  • Research Area:

    Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

  • Product Type:

    Primary Antibody

  • Background:

    MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

  • Clone Number:

    3D7-E5-D9

  • Gene Name:

    CRTC1

  • Recommended Dilutions:

    WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100

  • Swiss-Prot No.:

    Q6UUV9

  • Storage/Stability:

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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