Catalog Number:
E1KS2241Amount:
10mgKinase Inhibitor Name:
(R)-BicalutamideBiological Activity:
(R)-Bicalutamide is an active competitive non-steroidal androgen receptor antagonist with an IC50 of 0.17 μM for MDA 453 cells. (R)-Bicalutamide possesses virtually all activities. (R)-Bicalutamide is the leading antiandrogen. (R)-Bicalutamide is used for the treatment of prostate cancer and breast cancer. (R)-Bicalutamide prevents the activation of the androgen receptor and subsequent upregulation of androgen responsive genes by androgenic hormones. In addition, (R)-bicalutamide accelerates the degradation of the androgen receptor. [1][2][3]References:
[1] Bohl CE et al. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6201-6. [2] Masiello D et al. J Biol Chem. 2002 Jul 19; 277(29):26321-6. [3] Chen J et al. J Pharmacol Exp Ther. 2005 Feb; 312(2):546-53.Price:
211.2$M.W.:
430.37 Formula: C18H14F4N2O4S Solubility: Unknown Purity: >99% Storage: at -20℃ 2 years CAS No.: 113299-40-4Research Area:
Stem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal TransductionCatalog Number:
E011117-1Amount:
50μg/50μlReactivity:
HumanApplications:
IHC: 1:50~1:100Swiss-Prot No.:
P38398Price:
145.00$Catalog Number:
E011117-2Amount:
100μg/100μlReactivity:
HumanApplications:
IHC: 1:50~1:100Swiss-Prot No.:
P38398Price:
225.00$Catalog Number:
E011149-1Amount:
50μg/50μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P23458Price:
145.00$Catalog Number:
E011149-2Amount:
100μg/100μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P23458Price:
225.00$Catalog Number:
E011237-1Amount:
50μg/50μlReactivity:
HumanApplications:
IF:1:100~1:200Swiss-Prot No.:
P38398Price:
145.00$